The top names in pet flea control are Frontline, Advantage, Revolution and Bio-Spot. These on-the-spot type treatments for dog and cat flea problems all provide one month of complete protection. Advantage flea treatment kills fleas very quickly. The active ingredient, imidaloprid, acts as a nerve agent that fries their entire nervous system. Ninety eight to a hundred percent of the fleas on the animal die within 12 hours of application.